Showing posts with label W.H.O.. Show all posts
Showing posts with label W.H.O.. Show all posts

The A.D. Pandemic Hellyear of 2043-2044: An Overview (Part 3)

WORLDNET ARCHIVES ADVISORY: the following is an excerpt from a medico-history review article written in a dry, complex style with technical terms.

Title: “Retrospective of the 2043-2044 Amazon Disease Pandemic Hellyear: the rise and fall of a death dealer.”

Author: Xenia C. Diakos, Department of Public Health, Faculty of Health and Medical Sciences, Copenhagen, Denmark Sector, OmniEuropea.

Source: History and Medicine, vol. 2, no. 1, pp 127-172.

Date of peer-reviewed epublication: 08/11/2051.

 

[Beginning of excerpt] (…)

Incidentally, the emergency deputation of citizens wound up being embraced overwhelmingly by civilians both outside and within the refugee campswith at least stoic compliance, if not welcoming dedication. It was as if people had heard the call of citizenship responsibility to fight for civilized Humanity; alternately, it could have simply been a natural desire to preserve access to food and water, as well as remain protected from A.D for themselves and their families. Most likely, though, a mixture of these two not-mutually-exclusive motivations applied in the case of most deputized citizens.

By mid-April 2044, and as they welcomed a vital injection of ‘boots on the ground’ similarly armed and biohazard-protected via military equipment stockpiles, the armed forces could then rely on the support of these deputized militias to ensure a disciplined and efficient performance of their previous multitasking rolessuch as maintaining closed borders, upholding the inviolability of military bases and food reserves, defending refugee camps, assisting in maintaining order inside and outside the sanctuaries, or enforcing the perimeters of quarantine zones. Furthermore, this provided the military with much-needed leeway and personnel to finally embark on three additional endeavors that had previously been unattainable, let alone actionable: the enforcement of dusk-to-dawn curfews in all areas; the engagement and interdiction of violent activities everywhere; and the reopening of supply lines between hoarded emergency reserves and quarantine zones.

Such all-encompassing mission of restoring order and hope, however, wound up commanding its very own steep price in human livesfrom the inevitable high casualty clashes against a plenitude of rabid gangs, outlaw raiders, zealot throngs or rebellious marauders, to having no choice but to strife down riotous mobs at borders, quarantine perimeters, or established food and water distribution centers. And through it all, an unrelenting P. amazonia kept on wantonly reaping its own sizeable share of the deathly spoils.

Notwithstanding, chaos and savagery were being forced into a gradual retreat almost everywhere in the face of an unwavering alliance of soldiers and deputized citizens, bringing with them succor from anarchy, barbarity, and starvation, along with a lucid preparedness to deal death themselves if need be.

Consequently, by the end of May 2044, and thanks to an increasing pool of vetted, disease-free, and trained citizens, further expanding the numbers of deputized militia, power and communications were being restored, whereas the incidence of violent confrontations was already undergoing a declining trendalbeit remaining far from having dissipated entirely.

In other words: with the wheels of civilization being put back on their axel and set to spin anew, at least slowly, the grinding war for civilized Humanity was being won gradually in an overwhelming majority of countries in the world. But, this took many months and, unfortunately, a tragic degeneration into a cycle of violence and death nevertheless became the doom of some countries, as these devolved into hellholes of calamity through persistent barbarity and religious zealotry, coupled with an Amazon Disease kept unchecked by ignorance and paranoia.

Some of these nations somehow managed to reverse the tides of catastrophe to not only remain among the civilized nations of the world by the end of the pandemic, but furthermore join in what would be known as the ‘Big Reset’ (as discussed later in this review). Woefully, some others never recovered and instead remained violence- and A.D.-ridden disaster areas, to this day comprising a small group referred to as the ‘Dread Zone’ (also as further specified later in this review).

(As an aside, the former U.S.A. had almost gone the way of the Dread Zone; the anarchy, though, somehow morphed into their 2045-2047 Second American Civil War and resulted in the founding of the Christian Republic of the United States of Americaagain, as further explained later in this review.

The death dealer’s bane comes

During Humanity’s harrowing descent into darkness and its subsequentyet still-ongoingre-emergence into the light, the cloistered WHO-affiliated research teams around the world had seen their collaborative dedication and shared doggedness finally rewarded.

And thus, on the historic day of June thirteen, 2044, the announcement was made that science had bequeathed to Humanity a freshly forged tandem of sword and shield to vanquish its new, gruesome foe: the ‘Anderson-Connelly-Valence-Olbermann-Sheu’ (or ‘ACVOS’) vaccine, named after Stephen Anderson (former U.S.A.), Marie-Sol Connelly-Valence (Canada), Karl Olbermann (Germany) and Daiyu Sheu (China), whose teams provided the critical scientific discoveries and designs for the world-saving medicine.

In this respect, the ACVOS vaccine is in actuality an anti-A.D. vaccination strategy consisting of a three-pronged assault against P. amazonia’s unique disease-causing feature. First, the active vaccine uses as an injected immunogen a synthetic version of the protist’s fibrinogenase, with the latter’s fibrinogen-cleaving activity disimproved by artificial mutation. Second, a pharmacological thrombolytic agent capable of penetrating and dissolving efficiently the protective fibrin shells of P. amazonia is delivered over three days upon vaccination. And third, another pharmacological compound designed to inhibit specifically the fibrinogen-cleaving activity of the protozoan’s native fibrinogenase, thus preventing any ongoing or further formation of protective fibrin coatings, is administered over fourteen days after vaccination.

Therefore, during the minimal two weeks it takes for the immune system to produce antibodies aimed at the protist’s fibrinogenase, subsequently crippling the deadly trespasser while flagging it for termination by white blood cells, the previously insurmountable fibrin-coating defense of P. amazonia finds itself simultaneously stripped and nullified. To this effect, the ACVOS vaccine is highly efficient not only as life-long protection for those yet to be infected but also for those newly-infected while curing them of the developing disease.

Alas, the vaccine reaches its limits of effectiveness for those already into their fourth day after infection. By that time, the already occurring manifold emboli have begun to cause irreparable organ damage, especially to the brain, whereas the triggered and ongoing systemic thrombogenic cascade, along with the resulting incremental thickening and curdling of the blood, condemns to futility the administration of the active vaccine and its assisting fibrinogenase inhibitor and thrombolytic compounds.

So, even in the face of its imminent and total defeat, a spiteful P. amazonia still harvested every sown death that had already taken root.

Darkness persists in its last throes

The arbitrary madness that had gripped a suffering Humanity was determined to prolong its stranglehold, however. Following the news about the ACVOS vaccine, some of the survivors in quarantine zones wound up funneling their fears, their resentment, and their rage into various conspiracy theories that held scientists and other ‘privileged elites’ as scheming oppressors who sought to save themselves while leaving ‘common folks’ to die, or were responsible for the pandemic as an act of culling to remedy an overpopulated world, or caused the pandemic to enslave everyone with the promise of the vaccine as barter for the surrender of individual freedomsor any combination and variation of these. In a similar vein, the vaccine represented either the ‘Devil’s hand acting against God’s will’, or a ‘poisonous substance disguised as a cure to genocide the faithful’, in the paranoid and nescient minds of religious zealots.

As a consequence, there was an explosion of instances where individuals were beaten or slaughtered after their identification as (or ‘accused of being’) scientists, especially in the case of those suspected of having worked in any biomedical field prior to the pandemicand it didn’t matter if the targeted individuals were truly scientists or not. Even worse, in some parts of the world, simply knowing a little bit of science had come to constitute righteous justification for being assaulted or murdered.

In between, by the end of July 2044 and following the priority vaccination of soldiers, deputized citizens, refugee camp caretaking personnel, refugees, and those still awaiting admission into the camps, mass-vaccination campaigns in quarantine zones and everywhere else were initiated in earnest the world-over. On the surface, such an undertaking to save what was left of Humanity from P. amazonia seemed like an impossible task. However, a progressive upwelling of gratitude-driven volunteerism from the subsequently vaccinated, including those from quarantine areas, not only boosted the momentous endeavor into moving forward at an accelerated pace, but moreover, resulted in a further inflation of responsible and dedicated deputized citizens.

This was fortuitous, for the inflation of militia numbers meant an enhanced capability to interdict mobs and restore order. Moreover, this enabled improved protection of victuals and vaccine distribution centers, as well as vaccine production facilitiesespecially from ‘anti-ACVOS’ crazies. Incidentally, at the time, anyone attempting to steal or destroy batches of the active vaccine and its assisting compounds was shot on the spotno questions asked. All the same, it took almost six months of committed uprightness and determined organization to achieve vaccination of the bulk of the world’s survivors, with an additional dozen weeks or so before fulfillment of the endeavor.

Meanwhile, the madness and savagery returned at last to the deep recesses of the human psyche, thanks to the combination of unwavering and heavily protected supply lines, an accelerating restoration of power and communications, and a gradual re-establishment of calm and order.

And as all of this came to pass, an A.D.-vaccinated and enduring Humanity rediscovered a purpose other than individual self-preservation: helping others to help oneself, and pulling together to preserve what remained of civilization.

A rejuvenated sense of personal and communal responsibility blossomed among the survivors.

(…) [End of excerpt.]

 

(Concluded in Part 4. Read Part 1 and Part 2, if you haven't already)


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Psiarch® PHV

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The contents of Psiarch's Hideout are licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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The A.D. Pandemic Hellyear of 2043-2044: An Overview (Part 1)

WORLDNET ARCHIVES ADVISORY: the following is an excerpt from a medico-history review article written in a dry, complex style with technical terms.

Title: “Retrospective of the 2043-2044 Amazon Disease Pandemic Hellyear: the rise and fall of a death dealer.”

Author: Xenia C. Diakos, Department of Public Health, Faculty of Health and Medical Sciences, Copenhagen, Denmark Sector, OmniEuropea.

Source: History and Medicine, vol. 2, no. 1, pp 127-172.

Date of peer-reviewed epublication: 08/11/2051.

 

[Beginning of excerpt] (…) the center stage belongs primarily to the infamous protist responsible for the modern culling of Humanity through the Amazon Disease (A.D.), a unicellular organism which goes by the phylogenic classification name of Protocystis amazonia. However, to grasp fully the protozoan’s historic impact, one must track the sequence of events marked by its discovery and biomedical understanding in concert with the circumstances that underlined the emergence and spread of the pandemic it causedthe deadliest in recorded history.

How it all began

The then-existing World Health Organization (W.H.O.) first identified the infectious impact of P. amazonia as the ‘Thrombogenic Manifold Emboli Syndrome’ (T-MES) in July 2043. Then a brand new infectious disease of unknown agency appearing out of the Brazilian deforested parts of the Amazon rainforest, this syndrome distinguished itself by massive blood clotting resulting in rapid death by congestion of all vascular vessels of the body. 

The symptoms and course of T-MES are a matter of historical medical record. Early symptoms are deceptively innocuous over the first two days after infection, consisting of nothing more than a light fever, some fatigue, and intermittent coughing and wheezing. Although the light fever dissipates during the third day, the other symptoms grow in intensity as patients additionally suffer loss of appetite and difficulties in breathing. By the fourth day, the infected are nearly moribund; in addition, they experience loss of consciousness and intermittent seizures.  By the fifth day, they become comatose whereas the heart undergoes recurrent arrhythmia and the kidneys shut down; at the same time, forced oxygenation of froth-filling lungs is necessary to sustain shallow breathingat best. In the end, on the sixth day, the heart suffers terminal arrest with the circulating blood having turned into a slushy and clumpy, clot-filled goo. At the time, all the known medical interventions designed to dissolve blood clots were overwhelmed by such a swift and massive formation of an uncanny multiplicity of blood clots throughout the vascular system in just six days.

Unfortunately, Brazil initially shrugged off the W.H.O.’s warnings of an epidemic. Whether the health organization failed to impress upon Brasília the urgency of the situation because of incompetence on its part or that of the Brazilian government, or both, remains open to debateregardless, internal W.H.O. memos indicate the organization undertook in those early days preparatory measures for a global emergency, on account of its awareness of the unreceptiveness to health warnings of governments fixated on short-term budgetary considerations and economic interests, coupled with its in-house analytics of the frequency of emerging cases in Brazil which projected an immense potential for T-MES to become a wildfire-type pandemic. 

To this effect, the number of T-MES cases among Brazilians had exploded by November 2043. With the disease spreading unchecked, the W.H.O. had no choice but to officially declare T-MES an epidemic with a high risk of devolving quickly into a pandemic. At the same time, again as indicated by internal memos, various W.H.O.-affiliated physicians and scientists throughout the world were already working to not only identify the infectious agent responsible for the disease, but also gather insights into its mode of propagation.

Finally, realizing it had been caught off-guard by shortsightedness, the government in Brasília responded at last, but with a demonstrated lack of preparation and gross disorganization. Meanwhile, news about the Brazilian T-MES epidemic was spreading throughout the world: in turn, it did not take long for the syndrome to become known as the ‘Amazon Disease’, the ‘Blood Clotting Disease’, or the ‘Blood Curdling Disease’.

Notwithstanding the syndrome’s frightful impressions on the collective human imagination, all other governments of the world welcomed W.H.O.’s warning with dubiousness, citing unwarranted alarmism and past ‘overblown pandemic scares’ as rationalization. Instead, they reassured their populations with confident platitudes while refusing to waste personnel and money screening travelers for "signs of a basic cold"—as a result, they failed to recognize, or refused to acknowledge, the disease's seemingly benign, and thus insidious, early symptoms. In effect, this constituted W.H.O.’s worst-case scenario, as described in those internal memos.

Genesis of the death dealer

A month later, the culprit for T-MES was finally identified and its life-cycle uncovered. As it turned out, the origin of the Amazon Disease constituted a tale in two acts.

The story begins with Protocystis rodentia, a non-lethal protozoan parasite of rodent dwellers of the Amazon rainforest. Being transmitted through the saliva of various tick species, it lodges itself into the connective tissues of the infected mammals to form single-celled cysts to slumber, occasionally drawing nutrients to divide by meiosis and form gametocytes. These would be subsequently released into the blood stream to be picked back up by other feeding ticks, thereafter fusing with likewise-ingested gametocyte counterparts to generate new P. rodentia unicellular individuals ready and waiting to be transmitted in turn. 

Fortunately for Homo sapiens sapiens, especially for the lumberjacks, farmers, and villagers that had encroached on the sprawling Brazilian deforested areas, P. rodentia proved no match for the human immune system and, consequently, remained harmless and unnoticed.

Thanks to ever progressive deforestation, however, the increased contact between humans and Amazonian ticks amplified the exposure of the protist to human physiology: as a result, this imposed a natural selective pressure on it to adapt and better withstand the immune system of its new recurring host. Hence, after more than half a century of such selective drive, a newly-evolved relative of P. rodentia emerged to end the first act of the tale and bring about the second onestarring Protocystis amazonia.

The adaptive changes that characterize P. amazonia, and which make it so deadly to humans, rest primarily upon three single-base pair mutations within a gene that encodes one of its proteases. Proteases are enzymes that cut away at other proteins; they comprise a part of a microorganism’s arsenal of ‘forks and knives’ that allows it to derive nutrients from its host, such as the amino acids that make up proteins. Named ‘fibrinogenase’, this mutated protease of P. amazonia is not only kept at its cell surface but also cleaves precisely the blood-circulating protein fibrinogen to convert it into its clot-forming active formnamely fibrin, the main substance blood clots are made of. Furthermore, P. amazonia’s fibrinogenase cuts human fibrinogen only and not that of other animal species. In any case, once P. amazonia enters the human circulatory system through the saliva of a carrier tick, its fibrinogenase starts converting fibrinogen into fibrin, which, in turn, ends up cocooning it within micro-blood clots. 

Incidentally, with evolution being an imperfect process, this ability of P. amazonia to envelop itself with fibrin confers both advantages and drawbacks. On the one hand, this ‘fibrin shell’ provides protection from the human immune defenses, thus enabling its circulation unhindered in the blood stream while drawing nutrients from said blood to multiply by mitosis. Similarly, its fibrin coating also greatly reduces the effectiveness of protozoan-specific antibiotics, such as paromomycin, by acting as a physical barrier that keeps the microorganism out of their reach. Additionally, the micro-blood clots surrounding P. amazonia individuals enable them to leave passively the blood stream at the gas-exchanging interfaces of lung capillaries and alveoli, subsequently entering the lungs and producing an irritation of the airways which, in turn, causes a coughing reflex to expulse those same micro-blood clots. As a result, P. amazonia becomes airborne as its fibrin shell allows it to survive long enough to infect other human beings by inhalation, or by inert penetration through skin pores (Note: the same applies for direct contact with blood from an infected patient).

On the other hand, this very same fibrin cocoon prevents the microorganism from leaving the blood stream and crossing over to its host’s connective tissues in order to form cysts and produce gametocytes. As a consequence, P. amazonia is robbed of its means of gene pool diversification by sexual reproduction. Furthermore, with one of the causes of blood clotting being previously formed blood clots, the fibrin shells of individual P. amazonia inevitably grow in thickness and wind up imprisoning it, subsequently hampering its ability to multiply by mitosis, in addition to removing any further opportunities for diffusing out of the host’s blood stream and into the lungs. Lastly, the multiplication of circulating P. amazonia micro-clots, along with their incremental growth in size, triggers a progressive and amplifying cascade of systemic blood clotting that ultimately traps the protist within the curdling blood of its dying host, leaving it to succumb by attrition in the wake of the latter's death.

(And thus, the highly infectious, common cold-like symptoms of the first three days, followed by the next non-infectious three days of precipitated death spiral.)

Rise of the death dealer

Within the span of less than two weeks after the W.H.O.’s disclosure of its findings on P. amazonia, a multiplicity of A.D. cases was already erupting around the world. In cities, suburbs, towns, and villages, the disease preyed on everyone: from newborns to the eldest, from the destitute to the affluent.

On the twenty-first of December 2043, the W.H.O. firmly repeated its warnings of a pending worldwide pandemic. Although receptive on the surface, the collective response of the governments of the world proved tentative, if not incompetent: whereas they mandated quarantine protocols for all hospitals and healthcare centers with A.D. patients, at the same time closing their borders and shutting down air travel, they nevertheless hesitated to prohibit public and economic ground travel; in a similar vein, they procrastinated in putting under quarantine those areas with people already afflicted by the disease.

Furthermore, their political juggling acts of disseminating critical information about A.D., while in concert demeaning the danger it represented to reassure their populaces and avoid panic, resulted in sowing confusion on the gravity of the situation. In concert, this fostered a mistaken sense of lack of emergency within the public and private sector spheres. 

(It must be pointed out that, at the time, too many people remembered the relatively smaller-scale pandemic of twenty-three years earlier, which was characterized by back and forth confinement versus non confinement directives, the incompetent denials of the efficiency of wearing face masks followed by the justified imposition to wear them, curfews enacted and revoked in repetition, the consequent slowing down of the global economy, and the cyclic panic-driven hoarding of goods. Therefore, the governments of the world sought to conserve appearances by opting for the equivalent of tap dancing around the alarming truths of A.D. while simultaneously enacting the wrong lessons from past pandemics.)

In any case, these precarious and worsening circumstances were exacerbated by a dysfunctional coordination between all levels of governance in every country, from rural to federal. As a result, legions of misinformed individuals went about their regular business, such as shopping, commuting, working, clubbing, or driving off to visit relatives, all the while paying little heed to the W.H.O.’s recommended health precautions.

In short, in all countries of the world, the expansion of P. amazonia’s reach was facilitated and prolonged unduly. Case in point: the numbers of infected, dying, and deceased were increasing exponentially everywhere a mere week after the W.H.O.’s reiterated warnings of an impending pandemic.

In between, as revealed again by internal memos, W.H.O. had in foresight already mobilized discreetly its worldwide affiliated scientists, physicians, research staff, and care-providing personnel, having secluded them in designated, autonomous, and secure research facilities under the military protection of their respective countries, to undertake in earnest a collaborative search for an A.D. cure.

The death dealer also becomes a chaos-bringer

By the end of December 2043, frantic disorganization prevailed everywhere (…)  [End of excerpt.]

 

(Continued in Part 2)


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© PHV (Registration no. 1168315)

Psiarch® PHV

 Creative Commons License
The contents of Psiarch's Hideout are licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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